The For Any Corporate Risk Management Program Essay

For any corporate risk management program, there are a number of factors whose absence signals an increased likelihood of failure for the risk management program and whose presence greatly increases the chance for success of the program (Hillson and Simon, 2012). These factors, called Critical Success Factors (CSF), include the following: †¢ An organization supportive of the process; †¢ A skilled and competent staff; †¢ The presence of the necessary support infrastructure; and †¢ A simple, scalable, and documented procedure (Hillson and Simon, 2012). In the Environmental Quality International (EQI) in Siwa case study, some important details are missing, but with the information that is available, it is possible to draw conclusions about EQI’s risk management system and how the company reached the CSFs. EQI’s Critical Success Factors in Siwa CSF Examples Supportive Organization †¢ Company President’s personal project †¢ Fit company mandate to promote sustainable development †¢ Secured loans and other financing for project Skilled Competent Staff †¢ Neamatalla and his sister Laila were instrumental in success of phases of the project †¢ Use of local staff for reduces costs Necessary Support Infrastructure †¢ Loan money for project finance †¢ Evidence of willingness to address problems as they developed (mites in lumber, wages for women workers) Simple, Scalable, Documented Procedure †¢ No documented evidence of this CSF (Hillson and Simon, 2012) There were many benefits andShow MoreRelatedImplementation of Corporate Social Responsibility Programs by Foreign Subsidiaries716 Words   |  3 Pageswith a well-planned and defined strategic plan if they are to succeed with their Corporate Social Responsibility (CSR) programs, taking into account value creation, risk management and corporate philanthropy as part of their strategic vision for the programs. 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Life vs Death Euthanasia Free Essays

The word euthanasia is of Greek origin, which literally translates to mean â€Å"happy or good death. † However, since the beginning of the 19th century, euthanasia has become associated with speeding up the process of dying or the destruction of so-called useless lives. No longer true to its literal meaning, it is now a practice of deliberating causing or assisting in someone†s death. We will write a custom essay sample on Life vs Death: Euthanasia or any similar topic only for you Order Now Because it constitutes murder and is immoral, euthanasia should not be legalized in the United States. Almost everyone who attempts suicide or asks for assistance in their death do so as a subconscious cry for help (What†s Wrong With Making Assisting Suicide Legal? ). These people want to hear they are loved, not that someone is actually willing to assist in their death (Johansen). Many of these people have emotional and psychological pressures, which can cause them to choose euthanasia as a way to solve problems. Many are either depressed or dependent and are incapable of making well-informed decisions in that state of mind (Euthanasia:Answers to Frequently Asked Questions). The main concern for those who ask for euthanasia practice should be to give them emotional and spiritual support for their problems (Euthanasia : Answers To †¦ ). Tis type of counseling and assistance has proven to be successful. A study done on 886 people who had attempted suicide and been helped showed that only 3. 84 percent had gone on to kill themselves 5 years later. Another study showed that after 36 years, only 10. 9 percent had killed themselves (What†s Wrong With†¦ ). If euthanasia became legalized, it would be administered for those who are mentally unable to choose what is best, when they could instead be helped. Many who are in favor of euthanasia may say that a request to be killed is only justified when a doctor thinks a patient does not have a â€Å"worthwhile life† (Gormally). However, no one can judge the worth of a person†s life. â€Å"As a society, we are coming to understand that mere preservation of the flesh is not the highest value†. Many times it is the family of a patient who determines whether or not they live a worthwhile life depending on if they can participate in â€Å"normal† human relationships (Euthanasia Opposing Viewpoints 103, 117). Those who support euthanasia strongly believe everyone should have control over their own life and death and many who give â€Å"requests for euthanasia may indicate†¦ they are positively asserting their desire to control events† (The Case For†¦ ). However, the religious aspects to this issue support a different view. Religions such as Christianity, Judaism, and Islam hold life as sacred and believe it is a gift from God (â€Å"Euthanasia† FunkWagnalls). If the gift of life is from God, then only God can decide when that life should end, not someone else assisting in a death. Euthanasia is also considered immoral by these religions because the 10 commandments prohibit murder, which is essentially what euthanasia has become (â€Å"Euthanasia† Britannica). When many are suffering from a disease, they would rather die a dignified death than suffer tragically from the disease (The Case For Voluntary Euthanasia). Euthanasia activists claim euthanasia is â€Å"death with dignity†, even though the methods in which the deaths are carried out are anything but dignified. This can be supported by the euthanasia cases of Dr. Kevorkian, the â€Å"Doctor of Death† (Johansen). Dr. Kevorkian has used carbon monoxide to gas people to death, and has also had bodies dumped in empty vehicles in parking lots ( Euthanasia : Answers To†¦ ). Another example of how euthanasia killings are not dignified can be shown by the first televisioned mercy killing, which aired in March 1995 in Great Britain that caused the spark for the euthanasia controversy. The man who allowed cameras to be present at his death was a 63 year old patient of Motor Neurone Disease. Over 13 million people watched as he received a lethal injection by his doctor (Pratt). When these killings can be displayed for the public to see, they can not be considered dignified, especially by the means in which these deaths occur. If Euthanasia practices become legal, it would only legitimize these degrading practices. â€Å"Most elderly don†t fear death as much as they fear the pain and suffering†¦ † that may come along with it (Euthanasia Opposing Viewpoints 136). Because of this, some justify the euthanasia practice as a way to alleviate uncontrollable or intolerable pain that is placed on a patient. Even so, deaths by euthanasia are not always painless. Even a passive act of euthanasia such as the withdrawal of life support, food and water, can cause a slow and painful death (Euthanasia : Opposing Viewpoints 39). Death is also not the only solution for pain control. In fact, pain control has been perfected in the science fields, so that most pain can be eliminated completely or greatly reduced. Even though doctors are supposed to help control pain, many have never had a course in pain management and don†t know what to do (Euthanasia : Answers To†¦ ). Better education should be provided to health care professionals in order to help heal a patient, not harm them, or even kill them. Though euthanasia is illegal in most countries, where it is widely practiced, such as in the Netherlands, it has sometimes become involuntary on the side of the patient. Euthanasia is held accountable for 15 percent of deaths in the Netherlands, where patients actually fear being checked into hospitals (Johansen). Many times involuntary euthanasia occurs because the patient is incompetent to make decisions. Even though the patient may have written in advance a living will, a will in the United States that allows a person to make decisions on the type of treatments they would want if they were ill, a proxy can override these decisions. A proxy is usually a relative or friend of the patient that can make decisions for them if they are incapable of communicating on their own. This person could then cause the death of a patient, even if it is a passive act of euthanasia which is not doing something that is necessary to keep a person alive (Pratt). If euthanasia were practiced legally in the United States, it would become involuntary to the patient and possibly cause a larger percentage of deaths than it already does, as it has in the Netherlands where it is commonly practiced. It is also said that euthanasia would be for those dying from an incurable disease or intolerable suffering (â€Å"Euthanasia† FunkWagnalls). However, there is no real definition for an incurable or terminal disease, especially since modern medicine has lengthened life spans. Some say a terminal disease is a disease that can cause a death within 6 months, while some who are claimed to be terminally ill may not die for several years (Euthanasia : Answers To†¦ ). In 1976, the New Jersey Supreme Court gave permission to the parents of comatose Karen Ann Quinlan to remove her from the respirator that was keeping her alive. Even though she was expected to die immediately, she began to breathe on her own and lived another 9 years (Euthanasia : Opposing Viewpoints). Because of cases such as this that show fault in the definition for terminally ill, euthanasia activists change the term terminally ill to hopelessly ill or desperately ill. The definition used for hopeless condition includes those with physical or psychological pain, physical or mental deterioration, or a quality of life unacceptable to the patient (Euthanasia : Answers To†¦ ). With such broad definitions for the term, hopelessly ill could include mostly everyone. The legalization of euthanasia would entirely contradict the medical practices that were established in the Hippocratic Oath, an oath over 2500 years old. Medical students, upon completion of medical school, must vow : I will use treatment to help the sick according to my ability and judgement, but never with a view to injury and wrongdoing. Neither will I administer poison to anybody and when asked to do so, nor will I suggest such a course (Euthanasia Opposing Viewpoints 97). Even though neither the laws nor medical ethics say everything should be done to keep a person alive, the oath forces medical professionals to make a promise to help the sick (Maier). Doctors should be highly enough educated in order to make the best decision for each individual patient. Even if a person requests assistance in their death, it does not give the doctor enough reason to say euthanasia would be the best choice for that patient (Gormally). â€Å"Poisons†, as stated in the Hippocratic Oath, are not to be administered even though many mercy killings now are committed with â€Å"double effect. These are high doses of medicine that may kill a person faster (The Case for†¦ ). A high dose of a medicine is as much of a â€Å"poison† to a body as carbon monoxide, another means of carrying out the death, is. If euthanasia became accepted in the medical professions, it would be an immoral practice that would contradict its origins. For those who are pro-euthanasia, the laws pertaining to euthanasia are considered to be government mandated suffering. The other side to this argument is that these laws are not intended to make anyone suffer, but are instead created to prevent abuse and protect patients from bad doctors (Euthanasia :Answers To†¦ ). There is no actual provision in the legal systems for euthanasia. It is either considered murder or suicide in the United States (â€Å"Euthanasia† Brittanica). It can be a tough situation because on one hand doctors who force treatment against wishes can be charged with assault (Pratt), while if nothing is done to prolong life or if life-support is withdrawn, criminal charges can be also be brought on (â€Å"Euthanasia† Britannica). In the Netherlands, doctors can assist in a euthanasia death even though it is illegal without the possibility of prosecution and there, euthanasia has become out of hand (Pratt). With the legalization of euthanasia in the U. S. , laws and policies would be changed so that rights that would be given to others in order to intentionally cause the end of a life (Euthanasia :Answers To†¦ ). It would become an uncontrollable practice. Instead of legalization, laws on euthanasia should become stricter. Euthanasia has become a problem in the United States that would only become worse if it were legalized. Legalization of euthanasia can not be justified when there is no real determination for the definitions of many terms that play a major role in the euthanasia issue. The practice of euthanasia also carries out undignified deaths that are immoral. It has no benefit to the medical society and contradicts all medical ethics. Assisted suicide has also become involuntary, unsuccessful, and uncontrollable in other countries. For these many reasons, euthanasia should not become legal in the United States. How to cite Life vs Death: Euthanasia, Essay examples

Discounted Cash Flow Valuation Advantages and Pitfalls

Question: Discuss about the Discounted Cash Flow Valuation for Advantages and Pitfalls. Answer: Introduction: Calling a fund manager skilled is a rare phenomena. However, John Whiteman, the senior portfolio manager of AMP Henderson can be called as skilled with regards stock picking He as a portfolio manager does not look at the performance of a stock from a 2D perspective, rather looks at the stocks from a 3D perspective wherein not only quantitative but also qualitative analysis is done. Analysing the industry to which a company belongs is one of the feature of a skilled portfolio manager. John Whiteman has a growth approach and some fund managers who think that investing in companies whose prices will rise in future thus pulling the share prices towards upward direction are termed as skilled like John (Hoyle, 2003). He as a fund manager does not concentrate only on one sector but has ventured into banking, transportation, retail and food segment while forming the AMP Henderson Capital portfolio. Further since John Whiteman had confidence in his decisions and was aware of what steps he is taking, he is termed as skilled in the true sense. Further to this the fund managers use the discounted cash flow method while picking stocks as it helps them to make a more accurate analysis of the future performance of the stocks. DCF is a method of valuation which discounts the future cash flows from a particular stock at its present value. The method is complex yet DCF enables to give a more accurate return from ones investment after taking into account the time value of money. The said method offers a more transparent tool in the hands of the fund managers in accessing a companys performance. Although developing the DCF model is complex yet the shareholders and other investors get a clearer view with regards the factors that would drive the price of the shares of the company in future, the growth in the companys earnings, how efficiently the capital is being utilised, what is the cost of the capital and in what time gap will the company start growing (McClure, 2016). Another very crucial point to note while adapting this model f or computing the share value of a company is that manipulation by varying accounting practices is difficult. Another very striking part of this model is that it is often used a s a reality check by the fund managers. It provides a authentic value of the firm unlike the other methods such as calculating the P/E ratios. However this does not mean that the fund managers should depend solely on the DCF model. It simply means that they should give more weightage and trust to this mode as it enables to provide an fundamental value to the stocks in discussion. The DCF model uses free cash flows which is free from any kind of manipulative figures (Stephen, 2014). Lastly it also offers the fund managers to include major changes in the strategy formed by the company into the model thus giving it a clearer picture. Thus it is the best model to be used by the fund managers. References: Hoyle, S. (2003). Pick out the cash flow. Retrieved from https://www.theage.com.au/articles/2003/09/26/1064083189607.html?from=storyrhs McClure, B. (2016). DCF Analysis: Pros and Cons of DCF. Retrieved from https://www.investopedia.com/university/dcf/dcf5.asp Stephen,E. (2014). Discounted Cash Flow Valuation: Advantages and Pitfalls. Retrieved fromhttps://www.firmex.com/thedealroom/discounted-cash-flow-valuation-advantages-pitfalls/

Maybe Theyre Magic Essays - Maybe, Stephen Sondheim, Magic

Maybe They're Magic Maybe They're Magic Stephen Sondheim, in my opinion, is one of the most gifted lyricist and songwriters of all time. He uses many witty comparisons, beautiful allusions, and variations of tempo to give each song a uniqueness and identity of its own. This identity is also created for each individual character through the songs, and tactfully conveys their inner feelings. The song Maybe Theyre Magic is one small example of these classic Sondheim characteristics. Sung by the baker and his wife, the song is about their struggle to achieve what they want: to have a child. Discretely, though, each character's sense of self, and inner thoughts are communicated by the movement of the song; the way the characters bicker exhibits the gravity of the matter, and the audience can actually hear the thoughts in their minds. This matter of not being able to bear children is not a simply answered problem, and although this problem is very specific, the language used is very open-ended. This makes it easier for the audie nce to relate this story to obstacles in their own lives, and keeps them interested. Throughout the song the wifes dialogue is stressing that one must do whatever is needed to survive, and whatever it takes to get what one wants. She quotes, Everyone tells tiny lies, whats important, really, is the size. This song shows the realistic attitude, and stubbornness of the wife's character. She is also a character that is very persistent; her husband is pleading with her to go home, and trying to take her mind off the matter at hand, and she continues with her words. Finally, the bakers wife wins at her strategy to get her husband to cheat just a little bit to reach their goal, and so they're off to tackle the obstacle. A lot is also revealed about the baker in the song Maybe Theyre Magic; he does not say much during the song, but his few words show how he is struggling inside with the beliefs that his wifes opinion is wrong, and that he doesnt want to consider her opinion. This draws him out to demonstrate the era, as well, because he thinks that the woman's place is in the home, struggles with listening to his wife's opinion, and holds the position that he can do everything himself. The end of the song is quite funny, because it's final words are If the end is right, it justifies the beans! If taken at face value, this means that the action prior (tricking a boy into trading a cow away for some magic beans) will be justified. But it is also possible to read further into this comment and think none of this is really going to be important later, or That our lives aren't really important in the grand scheme of the world. thus another reason why Sondheim is a wonderfully creative writer. Music

Tips on Writing a Brilliant Persuasive Essay

Tips on Writing a Brilliant Persuasive Essay The target of any persuasive paper is to convince your audience of your own beliefs. In other words, you have to persuade that your strong idea is more legitimate than all other related thoughts. Usually, authors reach this goal through stating logical arguments and expressing their emotions. Evidence based on the most recent sources also works. A convincing essay can be written in many different ways. So, there is no single correct answer. Introduction Paragraph A persuasive essay also starts with an introduction. Here you can read more about general essay writing tips. Students are taught to divide any essay into three parts: introduction, body, and conclusion. In fact, introduction all alone can be separated into three parts as well. Thus, students have to write an attention-catcher, thesis statement, and preview. The last one figures as a summary, and it’s really hard to make a summary which consists of just one sentence. The first paragraph has to make the greatest impact on your reader. It should not contain any evidence or details, but an argument. Convince your readers to have a look at your presentation from cover to cover in the very first paragraph. Does it sound incredible? Well, a short course in marketing may improve your ability to influence other people’s minds. Actually, you do not have to be an expert to make a reader read your argumentative paper to the end. All you have to do is to: Choose an interesting and up-to-date topic Gather opposing views Collect relevant sources for evidence Arrange all facts in a logical order Take some real-life examples Defend strong viewpoint and state it in your conclusion By coming back to the introduction of your persuasive essay, we should say that reviewing the main points has to be composed of details. It should not be formed without any reasons. It is crucial to understand how to develop the beginning of your persuasive paper as it is the most important part of any school or college writing assignment. Help with Planning a Strong Persuasive Essay First and for most, a student has to select a viewpoint. Take into account what sides of the coin exist. Decide on which argument sounds more objective. Understand the goal of your paper meaning the solution you’re going to offer. Next, you should analyze your target audience. Who is your reader? Also, you’ll have to determine the reader’s position on the given argumentative essay topic. Is it the same as yours, neutral, or opposing? Anyway, you must provide enough evidence based on the credible sources to the entire audience. Research – find all up-to-date and relevant information Are the related issues supporting your point? It’s okay to feel you might be wrong. The main goal of the persuasive essay is to try to convince your reader in your skills even if he truth is laying behind. It is a talent to make people believe in what you say no matter what the facts tell. Go beyond your knowledge and experience – present something new in your paper. You may contact online experts to get more ideas for your persuasive paper. Check the prices right now! Format and organize your persuasive essay in a proper manner The structure is what really matters when you want to ensure people in your ideas and position regarding a specific topic. This is how presidents win elections. You have to keep just three things in mind: Your purpose Your audience Your persuasive essay topic Not to get lost in all those interrelated points, we would recommend making a list of all ideas for the convincing essay. It might be in the shape of bullet point. Create an outline and stick to it. Thus, you’ll never get lost in those bushes. Other Helpful Recommendations Every student must be well informed about the persuasive essay topic. If you have an opportunity to pick one on your own, it is necessary to make sure you have gathered enough primary sources. Also, check whether the topic is fresh and inspiring. The other helpful tips on writing a convincing paper include: Testing your thesis statement. It is the last sentence of the first paragraph which is known as an introduction, and it should sound rather convincing. It should always have two sides of the coin. It must be yet debatable and obvious at the same time. We mean that any good fact should still have an opposing viewpoint to be the main topic of a persuasive essay. Disproving the opposing arguments. You should research and study each opposing view deeply before arguing it in your paper. Moreover, your evidence should sound reasonable. Try to find mistakes and deviations in the words of your rivals. Supporting personal position with the credible evidence. It has to appeal to reason. The last logical action from our team is to share some tips on the evidence. To support the main argument of your persuasive essay, you have to involve several different tools: Arguments and Facts  - A powerful means of convincing. The persuasive essay may be based on your own experience, skills, investigation, and observation. Don’t fear to defend your point of view. Never confuse facts with truths. A "truth" is something many people believe and consider to be dogma. Statistics  Ã¢â‚¬â€œ It is an excellent support for any argumentative essay. Just make sure that your chosen statistics come from the credible and recent sources. Refer to them and cite whatever you consider being persuasive and interesting on the last page known as Bibliography or References. Quotes  - Direct and indirect citations from the topic leading experts that support position stated in your persuasive paper. They are usually invaluable. Examples or Templates  - Samples can turn any of your ideas significant for the society. They serve as the proof for your persuasive essay. Here are some samples of the most  popular persuasive essay topics: Anorexia or standard model body School uniform Encouraged abortions Drug usage These topics for essays are disputable, so they are excellent for the persuasive paper. Finally, remember one truth: it is crucial to pick the topic that is interesting for you. Another truth is that you can order affordable online help with any persuasive essay or another academic assignment at any time of day or night.

A View of Prejudice as Described in Lorraine Hansberry’s Play, A Raisin In The Sun

A View of Prejudice as Described in Lorraine Hansberry’s Play, A Raisin In The Sun A Raisin in the Sun A raisin in the sun is a play about an African American family that is going to receive an inheritance because of a death in the family. In this play their is sexism, racism, and many other cultural differences that we might not have been able to see if we were not in the minority until this play. The African American family in this play is the Younger family there are five youngers living in one small apartment. I think the most important family member is Mama, she is the glue to the whole family and keeps everyone in line. Then theres Walter lee Younger which is mamas son he works as a chauffeur and thinks he is head of the household. Walters wifes name is Ruth she usually minds her own business more than the rest of the family. Mamas daughters name is Beneatha younger she is an aspiring doctor and she knows she can do it even with her being an African American woman. Then theres the youngest which you do not really hear a lot about he is walter and ruths son his name is travis all he wants to do is have a real house. A Raisin in the Sun is a play about the Younger family and it is based in the 1950s while racism and sexism were still taken very serious by many. The Youngers are about to receive an insurance check for ten-thousand dollars which was a lot back in the 1950s. they are receiving this check because Mr. Younger mamas husband died and left them money to take care of themselves because he worked until the day he died. Everyone in the younger family want something different out of the inheritance money. Mama wants to buy a house where her family will not have to struggle anymore. Mamas son walter wants to buy a liquor store with his friends so he can give the family everything they need. Beneatha who wants to become a doctor wants the money to go towards her schooling so she can help people and prove everyone wrong. Ruth and Travis do not really want anything specific but, everyone to be happy. Ruth finds out that she is pregnant with walters second child which they dont have any room for and beenie says â€Å"where is he going to sleep the roof† and ruth gets sad and almost passes out. this shows that they are all under a lot of stress and ruth feels guilty for having another baby. While mama and beenie know about the baby walter doesnt find out until later when beenies friend from africa comes over and they go in the room. Beneatha has a friend from africa bring her things from his homeland so she feels like she is finding her true self which is saying that she doesnt know who she really is and she is supposed to be the one with the strong mind on her shoulders. When the inheritance arrives walter is has a nervous breakdown and leaves the house for a week or so and mama goes looking for him. mama doesnt like seeing her son sad so she eventually ends up giving walter half the money saying to put two thousand in a bank account for bennie his younger sisters schooling and to keep the rest for himself. the money that mama gave walter never gets put into a bank account and ends up getting stolen by his friend Willy Harris.Walter never gets to accomplish his dream of having a liquor store. Meanwhile when walter was losing over half of the inheritance money mama is buying a house that will fit their needs, is in a good neighborhood, and is in her budget. The house that she picks isnt in an African American neighborhood and so she gets a visit from the welcoming committee. A man named Mr. Karl Linder is the welcoming committee and at first the Youngers think he is a nice man and that he wants to help but, then they find out that he only wants to pay them off to not live in the white neighborhood. the white man says that he doesnt want to ruin the block with how much the people who live their work for what they have by â€Å"certain kind of people moving in†. This causes the Youngers to become closer and move in to the new house. Throughout the play their are times that i wondered why would or rather how could people be so set on ruining other peoples lives. I grew up with many different raced people around me throughout my life so i will never fully understand the thought process of racist people. The Youngers seem to be portrayed as hard working people and they want whats best for their family it doesnt make a difference what color they are i would of still watched it the same with no judgement. Racism in the housing industry has been peppered with racism even up into modern times. The racism that is in the housing industry today are not only Towards African Americans its hispanics, whites, and any race. White people can be put out of their house by hispanics that are in gangs and even by other white people throughout the united states. But, most of the racism is pointed toward hispanics and how everyone thinks if you are colored you need to be a gang member of if you dress a certain way you are a gang member. We see it everyday on the news how police officers are even racist and arrest people for no reason. No one knows it happens in the communities also. I have seen people get shot of badly hurt by people that are supposedly protecting their community, Everyone is a victim of some kind of racism in their life even when we are younger. I do not think that people should not feel safe in their own home because of neighborhood racism. In the CBS news Ilyce Glink says Although weve come a long way from blatant, in-your-face housing injustice, racial discrimination still exists, said HUD Secretary Shaun Donovan. Just because its become less obvious doesnt mean that its less harmful. This statement is completely true many people die because of community racism. Racism in A Raisin in the Sun is almost sickening to most people and i hope that more people see this play to help spread the word about how African American people were treated in the 1950s. Racism is still alive today through communities that want one color out of their neighborhood which is not right either. I hope people eventually learn how not to be racist.

Substance dualism is necessary for beings to have free will Essay - 1

Substance dualism is necessary for beings to have free will - Essay Example Since the mind is not physical, it cannot be bound by physical laws that govern the body, thus, beings are free not only to do as they please, but also to do otherwise than they usually do. In this respect, responsible human actions are not related to mechanical causation as presupposed by materialism, the philosophical belief that humans are physical beings whose motions are bound by laws of physics (Wartick). A strong sense of free will is supported by dualism, unlike other philosophical thoughts such as materialism because, according to Descartes, humans have an infinite will to act involuntarily and to be held accountable for their actions, and an understanding capable of showing those clear and distinct perceptions. This paper proposes that substance duality is necessary for individuals to have a free will, not only to do as they please, but also to do contrary to their conventional ways by building a strong case for duality and disqualifying contrary opinion. Intentionality, of ten referred to as the ‘of-ness’ or ‘about-ness’ of mental states is undoubtedly the strongest argument in favor of dualism (â€Å"Case for dualism†); physical objects are spatial and have specific shapes unlike mental states such as thoughts and senses that are non-spatial. However, physical objects cannot be about or of each other because ‘about-ness’ or ‘of-ness’ is exclusively a mental phenomenon that is not within the physical realms, therefore, the lack of an equivalent of the intentionality phenomenon in the physical reality is a strong case for duality. On the contrary, mental states have ‘about-ness’ and ‘of-ness’; for instance, if one thinks that a certain painting is beautiful, then it means that the individual’s thought that the painting is beautiful is about the painting and cannot be reduced to any conceivable physical fact about the individual’s mind. Additionally, the f act that the individual’s thought that a painting is beautiful is about the painting cannot be identified with their disposition to react in certain ways like exclaiming and marveling verbally after viewing the painting. In this respect, an individual’s thinking is beyond the mere predisposition or tendency to act in certain ways because if that was not the case then it would automatically imply that individuals would never be aware of what they were thinking about until and after a corresponding behavior has been manifested physically. The implication for this intentionality argument, therefore, is that intentional mental states are purely holistic in nature and are not dependent on any physical manifestation, and because of its intentionality, the mind is very distinct from material non-mental things that are purely physical and mechanical in nature. In this respect, since no physical phenomenon has that aspect, intentionality is not a construct of the physical world , but a mental phenomenon; the absence of a counterpart feature in physical materialism proves that it is possible for the mental to exist separately, unaffected by the physical. Following this intentionality argument, dualism provides strong case for free will because then it implies that individuals have a limitless capacity to think on their own accord and to act on their own accord as well, voluntarily. The intentionality feature makes a great case for the argument that the mind and the body are purely

Personal statement Example | Topics and Well Written Essays - 1000 words - 6

Personal Statement Example My excellent interpersonal skills help me to communicate business information to my target audience by preparing crisp and well thought out presentations. I consider myself a social person for I like spending time with my families and friends. Being the part of the local community, I also like providing my assistance at local events and for other social causes. I am currently studying at Mt San Antonio College and this is my third year of school. Most of my subjects in the school are business related and therefore my interest in this particular field of study has grown with time. Within all this while I have learnt that my courses are much more than business management. They are providing an experience to the customer that is not less than exceptional; while motivating the employees to deliver their best by fulfilling their responsibilities. The basic responsibilities of the employees should be the maintenance of loyal customer base, providing exceptional customer service, guiding the customers on the product information and applications, handling new merchandise and working as a team to achieve mutual organizational objectives. All these factors contribute towards the success of an organization and therefore I have tried my level best to learn these skills through practical and theoretical knowledge. My father is an entrepreneur and is running his own business for almost 15 years. As a child I accompanied my father to various business meeting and negotiations. I heard my father and his employees discussing about the current economic conditions of the country and status of the stock market. Although as a kid I did not have much knowledge about all this but as I grew up, I started finding this subject interesting. I eagerly started waiting for my father to ask me to accompany me at the business meetings or negotiations. It was in the first year of my high school that I started watching businesses news for studying the position of several

McAfee Spyware Blocker Essay Example for Free

McAfee Spyware Blocker Essay McAfee, an Intel company, has been an industry leader for antivirus software to protect personal computers for many years. The company has expanded its services from protecting computers to also protecting cellular browsing as well, the software can be used on the iPhone, and Android phones. Product McAfee is introducing a new line of software designed specifically for Android and iPhone devices to block unwanted spying from applications downloaded on the mobile devices. McAfee Spyware Blocker will target applications designed to collect personal and private information. The applications on the users phone that are targeted are; photos, email, browsing history, camera, contacts, passwords, and all information posted in mentioned applications. Mission Statement McAfee Spyware Blocker for the iPhone and Android follows the same mission as the products for its personal computer software. Our mission for the McAfee Spyware Blocker application is to protect each client’s identity and personal information while using their mobile device with an advanced innovative software program designed to protect all information on the mobile device. The McAfee Spyware Blocker will filter all movements on mobile devices and warn the user with unwanted tracking, or spying from developers of applications. This also includes third party applications such as the popular Facebook, Pinterest, Yelp, Instagram, and other social media sites who require access to the users information. Customer Need As the first of its kind, McAfee Spyware Blocker, has set itself apart from other spyware blockers. The software provides protection on mobile devices, and from unwanted sharing of information when downloading applications. The software creates a separate profile based on user preferences, which block all real information of the user. It then forces applications to use false information, created by the user, to run applications that require access to personal information. Clients of McAfee are guaranteed by the history of the company, and its proven success and growth of its other products, which set the company apart from the current competition. The company is in constant development of its products to improve, grow, and meet the quick changing needs of technology and clients. McAfee follows trends and see’s the need for an advanced spyware blocker for the mobile market. The division has developed, what it feels, is an advanced, superior product for its current client base, and has developed a plan to achieve a new market of customers. Vision Model The vision of the McAfee Spyware Blocker is to create the best mobile spyware blocker in the market. The company started with the iPhone and Android markets first, but will add the iPad, iPod, tablet, and eventually all wireless devices. Wireless devices could potentially allow applications to be hacked and monitored for personal and private information. With the growing market of personal mobile and wireless devices, McAfee will continuously grow and advance the current software technology. The advances developed will provide upgrades for current clients and new software for new devices and platforms. The demand for privacy protection in today’s quick moving and growing technology market speaks volumes for the need for new advanced software for the growing community of mobile and wireless devices. The decision to create the McAfee Spyware Blocker division and be a leader in the market was an easy decision, and one that will grow the company in the direction of the ever-expanding technology movement. Business Model Throughout the history of McAfee products, the growing development of new technology has brought about a high demand and need for protection of client’s information. The need to protect clients has grown from personal computers to mobile and wireless devices and has our clients asking for more advanced protection while using an array of devices Mobile browsing on an Android or iPhone device, allows spies to access personal information. In recent years, breeches have caused an increase of identity theft directly related to mobile devices. The information stored, or applications used while on the device are likely to provide an expert hacker to gain valuable personal information. To satisfy the consumer need for protection, McAfee developed the spyware blocker division. The value created to offer advanced protection while operating the Android or iPhone devices, is unparalleled to any other spyware protection claims. No other spyware developed by competing companies has provided the user with absolute confidence of protection while using their mobile device. The software is an advancement of our current products, and the basis of the spyware is the same as in our other products. Because we have added to an existing product, the product, planning, development, and creative costs were minimal in relevance to the overall product offered. The company will continue to develop products that are on the cutting edge of what is going to come in the future. By utilizing the current software platforms, coding, scripting, and language, we are able to make advances quickly and cost effective. McAfee Spyware Blocker will continue to grow and develop as the market grows, and technology advances to include new products, McAfee, Inc. (2014). Vision, Mission, Value The previous launch of the McAfee Expanded Data Security, Application Security, and Ease of Administration in 2012, protected users from browser invasions. The applications, however, did not stop companies from using information from a clients phone, McAfee, Inc. (2014). The previous launch of mobile device protection, allowed McAfee to move in the direction of advanced mobile and wireless protection, by the development of the McAfee Spyware Blocker. The company continues to move in the direction of technology development and advancements and the need to create software to protect clients using multiple platforms, and from the creators  of applications that require access to personal information. The vision and mission of McAfee have always been to protect and provide its clients with the most advanced software protection from spies and hackers. The decision to create a new line of defense against advanced hackers and spies came from the need to protect against unlawful privacy breeches. The value of the product could be described as valuable beyond any dollar. To sell the product, the cost to produce, and the market value of the product describes the cost of the product to be $59.99, which will include any follow-up updates, McAfee, Inc. (2014). Vision, Mission, Value Summary The vision of McAfee Spyware Blocker is that each client will feel secure and trust that their information is protected on their Android or iPhone devices, and in the future, other wireless and mobile devices. The future of McAfee Spyware Blocker, according the analysis of the market research, shows that the software will continue to grow with demand of its clients and technology. The mission of McAfee Spyware Blocker is to be the best in the market, to out sell, out develop and outshine the competition. The ability to build and expand on an existing product to provide clients the best possible product has allowed McAfee to be a leader in spyware blocking software. The employment of highly knowledgeable employee’s of McAfee products gives client’s confidence in receiving assistance with the product Employees will have vital knowledge of the product and how the product works. Having extensive knowledge the users platform (Android/iPhone) will not only give confidence to the leaders of the McAfee Spyware Blocker, but also the end users of the software. Protection of personal information is priceless. Everyone, including the leaders at McAfee, want protection from theft of information. The McAfee Spyware Blocker gives all users exactly that, protection. The stated value  of $59.99 for the product does not include the value of protection, that is the additional bonus of the software. Principles and values The principles and values of the McAfee Spyware Blocker division follow the same guidelines of the company, McAfee, Inc. (2014). Listed below are the five principles of McAfee: 1.Conduct business with honesty and integrity 2.Follow the letter and spirit of the law 3.Treat each other fairly 4.Act in the best interests of McAfee Spyware Blocker and avoid conflicts of interest 5.Protect the company’s assets and reputation, McAfee, Inc. (2014). The company’s business values in the division of McAfee Spyware Blocker follow directly in line with McAfee, Inc. They are listed as: 1.Expertise – We have a deep mastery of digital security, and we never stop building and improving our expertise. 2.Partnership – We have a true sense of teamwork and partnership across McAfee functions and with channel partners and customers, developing collaborative solutions that offer tangible benefits. 3.Integrity – We’re in the business of protecting data from the unscrupulous, performing to the highest standards of ethics and responsibility. 4.Results – We have definitive goals with definitive outcomes, always striving for higher performance and never losing focus. 5.Courage – Being always ready is a requirement for courageous leadership across our business. We’re never intimidated by the audacious challenges we face every day, McAfee, Inc. (2014). The division of McAfee Spyware Blocker promises to be innovative regarding new technology developed for Android, iPhone, wireless devices, and other devices as they grow and change. The spyware blocker software will continue to advance and grow as the malicious methods of unscrupulous individuals and companies develop new ways to spy. References McAfee, Inc. (2014). McAfee for Consumer Retrieved from http://home.mcafee.com/?CID=MFEen-usMHP001 Pearce, J. A. II. (2013). Strategic management: Planning for domestic and global competition (13th ed.). New York, NY: McGraw-Hill. Thompson, A. A., Gamble, J. E., Strickland, A. J. (2012). Crafting and executing strategy: The quest for competitive advantage (18th ed.). New York, NY: McGraw-Hill.

Teenage Life Essay -- essays research papers

People who are nostalgic about childhood, were obviously never children. Few people can remember the truth about adolescence. Their minds "censor" their memories; and have them believe that being a teenager was was one big party, free of cares and responsibilities. Well let me say this, you couldnOt be more wrong if you had a lobotomy. There aren't that many adults around who realise what adolescence was really like. The anguish, the fear, the anxiety, the stress. People don't remember those problems because they want to forget them. The truth of the matter is, is that being a teenager is hard, right from the beginning, and it doesn't get any easier. We are such easy prey for big name companies who advertise using the pressure of popularity, looks and sex to force us to buy their product that, as it turns out, we never wanted or needed in the first place. Our lives are filled with stress. One of the greatest sources of pressure is school. Where we are herded like cattle from room to room, chewing on our cud, while the hay of knowledge is force fed to us as we are trying our hardest to gulp it down as more and more is shovelled in. Another great source of pressure is ourselves. We try our hardest to be accepted among a certain group or circle. Whereas most of the time we are rejected and we become depressed. Depression, another problem, along with ignorance and apathy that thwarts our lives. A wise man when questioned about his view on ignorance and apathy, said &...

Orthodox Jewish Wedding Essay

Marriage is normally a ceremony done in churches, in government premises, or in modern ones like beaches and gardens. It is usually done as a sign of love between two people. Marriage used to be a very sacred ceremony as two people say their vows to each other. Different cultures do this in different manners. In this paper, we will discover how the Orthodox Jewish wedding is done. This would prove the diversity of cultures in the world and how the Jewish community carries out their traditions and belief. This is divided into three parts that include the preparations done before the wedding, the set up days before the wedding and the wedding proper. When two people fall in love, what they want to end up mostly is a bride and a groom or a husband and a wife. Although it is altered by some other reasons in the modern times, the idea of marriage is still considered sacred by most of us. Although socio-economic status, health, dynasty and other things affect the people’s view on marriage, we still cannot take away the fact that the people who get married always ask for a happy life. Whatever reason they may have, the bottom line is still that they are searching for contentment in any way. A Jewish wedding day, the same with all other religions, is something that they really celebrate. Different kinds of rituals happen weeks before and during this day, in consideration of their history and heritage. As soon as the couple gets engaged, rituals already take place. It includes breaking a plate to represent the temples in Jerusalem that were destructed. It is to signify that even if they are enjoying in the celebration of the wedding, they are still saddened with the fact that these temples were destroyed before. It is also usual for the parents to do the arrangement of the wedding, with the help of someone like a match-maker called Yenta. Although this is so, the groom is still required to ask the bride’s father for her hand in marriage and to pay a dowry in exchange of the bride (Retrieved on December 11, 2008 from http://www. bbc. co. uk/religion/religions/judaism/rites/weddings_1. shtml). Judaism sees this practice as sacred. They think that without a man and a woman, each of the sexes will never be complete. They complement each other and each compensates what the other loses. They also teach in their doctrines that any person without getting married doesn’t experience the absolute joy and contentment in this life. It means that being married gives satisfaction to people, especially when they are blessed by God. When referring to marriage, they usually use the term â€Å"sanctification† which usually refers to the spirituality of the bond that binds two people and of the commandment made by God. They also see it as something that has a purpose. They view marriage as a perquisite to reproduction and friendship. It is both procreation and companionship. In the bible, as they believe, â€Å"It is not good for a man to be alone†. It is also a practice of each person’s legal rights through a contractual agreement where they sign on. Although there were times when the Jews were dispersed all over the world, they are still successful in preserving this practice as they live. This is probably because they really believe in the practice, because through it, history proves that families stayed stable and happy when they underwent the same kind of marriage . Jewish weddings are almost the same. They are made easier by the Rabbis by asking for a very minimal requirement. The Rabbis is the one who makes the laws in this kind of ritual (Retrieved on December 11, 2008 from http://www. confetti. co. uk/article/view/5054-7598-0-). Marriage in the Orthodox Jewish is very much full of traditions that show practice and devotion. In planning their weddings, every detail is very important. They take the preparation as a challenge of their capacity and a challenge to celebrate the wedding successfully. They pay too much attention to all the needs of the ceremony that makes every wedding a perfect one. The Orthodox Jews are believed to be the strictest among the strands of the Jewish faith. Their wedding ceremony is done by combining the legal and religious aspects of marriage. In case one of the couple is non-Jewish, he or she is asked to convert to the same religion. They believe that happiness cannot be achieved if they don’t undergo marriage, which is a license to fulfillment in the world. Also, it is said that when they get married, they don’t just focus on material and temporal elements of the preparation, but they also assure that their doctrines are properly carried out and that their spiritual and moral preparedness is enveloped on the marriage itself. It just proves that although their marriage is after a good life on earth, they still put in more consideration the supernatural and their religion per se (Retrieved on December 11, 2008 from http://www. confetti. co. uk/article/view/5054-7598-0-). Planning an Orthodox Jewish wedding is very tedious. They must consider a lot of things for them to be able to come up with a successful one. Most of the Jewish couple provides a planner that would make it easier for them to see chronologically their plans and the specifics of the ceremony. Through that, they will be able to get organized and efficient in the planning of the main event. The date of the wedding is usually known after they already register with a synagogue and Rabbi at the Chief Rabbi’s office. The time of the day and the day itself are also given much attention to in planning a wedding. It is usual to marry in the afternoon or in the evening, but you can also marry anytime of the day according to what the couple desires. Most of them, however, choose to marry on days like Sunday and Tuesday. It is also not allowed to do the wedding three weeks between July and August and on the Sabbath of festival days (Rosh Hashanah, Yom Kippur, Passover Shavuot, and Sukkoth). In case, they want to get married on a Saturday, they prohibit doing the ceremony earlier than two hours before the sun is down (Retrieved on December 11, 2008 from http://www. onfetti. co. uk/article/view/5054-7598-0-). In general, the first thing to do in planning it is to choose a date that they both want. They usually choose special days like the birth or the death of their rabbis to make a more meaningful celebration. Like other people getting married, they choose a date that means something to them or a date that is significant in their relationship. They also must specify a place or a venue which has enough space for dancing and a wide area where you can put a divider to separate men and women for modesty’s sake. They are very much particular with modesty which they can prove by separating people of different sexes during the wedding ceremony. They must also choose a rabbi to preside the wedding ceremony and a sofer or a Jewish scribe to take charge of the Ketuba or the marriage contract. After that, they must tell their relatives and friends about the wedding and invite them to attend on it. Attendees on this kind of practice matters a lot to the couple because the wedding would not mean anything at all without the presence of a specific number of people. Once they confirm their attendance, they can already inform the caterer about the approximate number of visitors. This is usually done to avoid hassles to both families of the groom and the bride and to assure that everyone eats enough as they celebrate that most important part of their couple life. After that, they must inform those people who are taking part in the wedding to dress accordingly. This is also a sign of respect to the practice. The female ones must use clothes covering the knees and the arms to the elbows, while the married ones must cover their air. Men must wear yarmulkes. The couple must make the wedding canopy from a cloth that is velvet or from a prayer shawl. This is to signify the clouds that helped Jews with everything when they were in the desert. They must make sure that they have the dress, rings without anything engraved in them, and the other things. The bride must make sure she has a veil thicker than the others’ to wear it on the wedding day. From that, they must find a schedule to do the veiling ritual prior the wedding ceremony. It is said that such a practice symbolizes the biblical story that happened between Jacob and Rachel, when they planned to get married. They must assign seven men to utter the words of blessings with a wine. Lastly, they must secure a room for the couple where they can spend on after the wedding proper. They are expected to stay there before they eat and spend time together alone for a certain period (Retrieved on December 11, 2008 from http://www. ehow. com/how_2077192_plan-orthodox-jewish-wedding. html). The wedding invitation is usually two sided and has an English translation at the right side. It does not ask for the person’s presence, instead it is asking people to â€Å"dance at† or â€Å"share in the joy of†. In this kind of ritual, visitors are very important, because they play a very vital role in the process. The copies of the invitation may be distributed and may be given by the couple or both of their parents. Sometimes, the invitation also includes biblical quotes to explain people why such thing is done or to further elaborate the importance of each part of the program (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). All of the guests are provided with copy of the program for them to know exactly what part they are in during the wedding proper. It may also include some Ketuba texts, the vendors’ names, a note coming from the bridal couple and some explanations of the different elements of the ceremony. This is also done to avoid unnecessary noises when they ask others why a particular thing is done (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). The Orthodox bride must prepare something white, while the groom must have a short white linen robe called a kittel. The bride is also expected to visit mikyah in the morning of her wedding. This is done to make sure that the bride undergoes a ritual bath that is believed to purify her and to make her a better woman as she gets married (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). It is also a must, that in able for a couple to get married in the Orthodox Jewish tradition, it is a perquisite that their parents also married in the same manner. Usually, both of their parents underwent the same practice. If in case their parents did not undergo the practice, they must talk to the rabbi for clarification. The ceremony includes singing and reading from the psalms. The wedding usually takes an hour before it finally ends. The wedding can actually occur anywhere, depending on what the groom and the bride choose. Given a desired venue, the bride or the Kallah and the groom or the Chatan, must stand under a canopy. The venue as chosen by them is usually paid by the bride’s parents. The validity of the wedding depends on the number of males present. There must e ten of them, which in their tradition, is called minyan (Retrieved on December 11, 2008 from http://www. confetti. co. uk/article/view/5054-7598-0-). Prior to the ceremony, the groom may spend time with his friends as eat and drink together on a table, called chassans tisch. Brides, on the other hand, take three or seven times circling her groom which is also a practice based on their bible (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). When the guests arrive on the wedding day, males go with the groom in a certain room, while the female ones go with the bride in another room where she sits on a throne-type chair. This is called â€Å"public beckoning† and may be spent with just family and other guests (Retrieved on December 11, 2008 from http://www. eddingdetails. com/lore/jewish. cfm). A service usually starts with the opening from the rabbi, followed by a bride being escorted to the canopy. It is then followed by a ritual of circling the groom by the bride. This also has a hidden meaning. The benedictions are read after and then the sharing of the cup of wine. The exchange of the rings is then done, followed by the reading of ketuba. Another cup of wine is offered which is shared by the groom and the bride. It was first blessed and told with a prayer for the companionship and joy of the newly wed. Later on, they are proclaimed as husband and wife and they are showered with rice and are greeted with a toast (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). During the marriage proper, the groom is asked to read from the Torah. That ritual is called Aufruf. Further, it is like a way of congratulating the couple, and letting the public know that they are getting married soon. In the same practice, some brides throw candies and nuts as he finishes the recitation of the benedictions. Through that, they are able to ask for a sweet and fertile life. The groom gives his bride a ring that is a sign of love. It is put on the bride’s right index finger, up to the second knuckle. It is so, because they believe that such a finger points to the soul and that it is used in pointing when they are reading the Torah. On the contrary, she puts the ring on his left ring finger. As they are doing this, they are reciting a Hebrew statement called haray aht (Retrieved on December 11, 2008 from http://www. weddingdetails. com/lore/jewish. cfm). In summary, preparing for the Orthodox Jewish Wedding is no easy thing. It requires a lot of effort to come up with an acceptable wedding that takes in consideration both the earthly and the religious aspect of life. Through this paper, we can also picture that even if there are still more days before the wedding, the people are already busy planning the event and are already doing some practices for the benefit of the big day. The wedding proper shows that values of these people as they do the rituals associated with getting married. It is also very obvious that they are really trying hard to avoid getting away from the proper way of doing it. Before and after the wedding, they are very optimistic about their, because of their trust to the Almighty. Everyone is looking forward to a happy and a blessed life ahead as they undergo the blessing of God through marriage. Celebration of their wedding is really something that the Jewish community must really be proud of. It is full of traditions that only their group inhibits and practices as well. Their culture is very rich and admirable. This is only a proof that cultures vary from place to place and that each culture has its beauty that everyone can admire. It is the Jewish community’s pride to have this and definitely, there are not just proud, but happy about acquiring this kind of culture.

Following a Journalist

Robert J. Samuel persuasive style emphasizes his view on the economy and how it has its ups and downs. He uses literary devices such as rhetorical questions and diction to achieve effectiveness with his persuasive style of writing and to show his purpose of his articles, his purposes are to make the readers reading his article start to see how the current economic states of some nation are. Samuel has a persuasive style of writing; to show that he has persuasive style of writing he uses rhetorical questions. For instance, Samuel asks a question that already has the answer to it, â€Å"Can anyone doubt that the euro’s creation in 1999 was a huge blunder? † This question shows how Samuel style of writing persuades the reader to understand his point of view by presenting them with a question that has only one answer. This question is worded in a way where the only logical answer is that it is a â€Å"huge blunder†. Furthermore, Samuel asks another question that has the answer to it, â€Å"Wonder why government can’t restart the sluggish economy? The obvious answer is that the government can’t restart the sluggish economy because the economy is in such a bad spot the only thing to do is fix it. This shows the persuasive style of writing that Samuel is expressing because he’s trying to persuade his readers that the government is doing nothing to help the economy. Samuel also uses diction to express his persuasive style of writing. For example, Samuel uses the world â€Å"dreadful† to express his claim on how bad the Obamacare policy is. The word dreadful means great suffering or extremely bad, when using that word he sends his reader the message that contributing to the Obamacare policy will bring great suffering to many people. When using the word â€Å"dreadful† it persuades the readers who read Samuels articles to be against the Obamacare. In addition to how diction is used in Samuels’s persuasive style of writing, Samuel uses the word â€Å"poisoned† to show how corrupted the political climate is. The word poison means toxic substance or negative influence, using that word sends the readers a message that the political climate can poison their minds with negative influences and that it could harm them not physical but mentally. When using the word â€Å"poisoned† it persuades the readers who read Samuels’s articles to resent the political climate because it is â€Å"poisoned† and it will poison them if not avoided. Samuel emphasized his point of view and clearly defined it for the reader in a way that convinces them to believe it with his persuasive style of writing. His purpose to most of his articles is to make the readers start to see how the current economic states of some nation are and how some nations economy have their ups and downs. To show his purposes he uses literary devices such as rhetorical questions and diction to achieve effectiveness with his persuasive style of writing.

Routers essays

Routers essays A router is a general device that is used to segment a network, with the goal of limiting broadcast traffic and providing security, control, and creating multible paths. It is a device that connects multiple LANs at the network layer and has access to network addresses, and it operates with respect to protocols. Routers have advantages as well as disadvantages. Among disadvantages, this device is new in the market, and thats why the price range is kind of high. But the good side is as more they are being used in the market today, the price is being lowered. Another disadvantage is, it is a very protocol oriented device and to maintain the framework it uses very large applications, such as operating system and management software. It provides firewall service and economical WAN access. Similar tobridge a Router provides filtering and bridging functions across the network. This device converts LAN protocols into WAN protocols and performs the reverseprocess at the remote location. It can be used for point to point network and in certain situation router combines bridges or work as a bridge for the LAN. It offers more intelligance, and has more complex network and traffic control management than bridges do. Routers have the potential for flow control and error protection. There are two types of routing that a router uses, static routing and dynamic routing. Static routing is when the network Managers configure the routing table to set fixed path between two routers. If a link goes down, it will issue an alarm but would not reroute the traffic. Dynamic routing is when the router reconfigures routing table automatically and recalculates the most efficient path interm of load, line delay and bandwidth. Some of these dynamic routers even balance the traffic load across multiple links and allows many links to handle peak traffic conditions. Routers are classified as their service capabilities and workload. There are th ...

Projects, Processes and Systems Essay Example | Topics and Well Written Essays - 2000 words

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Drug â€excipient Interaction of Anti-tubercular Drugs

Drug –excipient Interaction of Anti-tubercular Drugs Drug –excipient interaction of anti-tubercular drugs and its in-silico evaluation Abstract Isoniazid and Pyrazinamide are the first line anti tubercular drugs. Lactose is mainly used as the excipient in solid dosage forms of isoniazid and pyrazinamide. These drugs contains primary and secondary amino functional group which interacts with lactose by maillard reaction and form adduct. The maillard reaction adducts of isoniazid and pyrazinamide with lactose were synthesized at 60oC in alkaline borate buffer pH 9.2 and characterized by UV, FT-IR, DSC, HPLC and MS. Docking study for in-sillico evaluation of isoniazid-lactose adduct and pyrazinamide-lactose adduct was performed to study its effect on pharmacological activity. The present study shows the presence of incompatibility between isoniazid and pyazinamidewith lactose which leads to loss the therapeutic effect of isoniazid and pyrazinamide. Keywords: isoniazid, pyrazinamide, lactose, maillard reaction, excipient, incompatibility, dosage form. Introduction Excipients are traditionally better known as promoters of degradation than as stabilizers of drug substances (Crowley 1999). Physicochemical and physiological process e.g. stability, physiological pH, gastrointestinal transit time, disintegration, dissolution, permeability and bioavailability can be altered by drug excipient interaction (Jackson, Young et al. 2000). The interactions of drug with excipients can leads to changes in the chemical, physical and therapeutic properties can be termed as incompatibilities (Chadha and Bhandari 2014) and it may cause the drug degradation (Narang, Desai et al. 2012) and loss of pharmacological activity (Patil and Patil 2013). Lactose is most widely used as the excipient in the solid dosage forms. Lactose is available in different form and different grade with different physical characteristics. Lactose is very popular excipient because of low cost and inertness but in other hand lactose have interaction drug with amino functional group i.e. lact ose undergoes maillard [Monajjemzadeh, 2009]The maillard reaction is named Louis Maillard who reported over 80 years ago that some amine and reducing sugars interact each other and forms brown pigments. The first product of this reaction is simple glycosamine (Wirth, Baertschi et al. 1998). In this study, we attempted to explore the modes of interaction and energy binding of the different isomers of isoniazid adduct, pyrazinamide adduct and also study the biological activity of isoniazid adduct and pyrazinamide adduct compare with the help of various molecular modelling techniques. In treatment of tuberculosis, isoniazid and pyrazinamide are key components of first line regimen (Hemanth, Sudha et al. 2012). Isoniazid is chemically isonicotohydrazide and pyrazinamide is chemically pyrazine-2-carboxamide. Isoniazid and pyrazinamide is susceptible for hydrolysis and oxidation interact with excipient particularly carbohydrate and reducing sugars to form hydrazones. The hydrazone is mainly form by the interaction of isoniazid with lactose. There are also reported incompatibilities between lactose and other drugs containing primary and secondary amino functional group (Haywood, Mangan et al. 2005). In this study we were investigated the interaction between lactose with isoniazid and pyrazinamide for that different analytical technique were used and also done the in-sillico evaluation of isoniazid and pyrazinamide. Materials and methods Materials Isoniazid and Pyrazinamide was generously supplied as a gift sample by Macleods Pharmaceuticals Ltd., Wapi (Gujarat), India. Lactose monohydrate was purchased from Merck, Merck specialtiesPvt.Ltd. Mumbai, India. All other chemicals were of high-performance liquid chromatography (HPLC) and analytical grade. Methods Analytical methods UV-visible spectrophotometry The Ultraviolet-visible spectra of Isoniazid, Pyrazinamide and the Isoniazid–lactose adduct, Pyrazinamide-lactose adductwere recorded on a double beam UV-visible spectrophotometer (UV-1700; Shimadzu, Japan). An accurately weighed quantity of about 10 mg of isoniazid, 10 mg of pyrazinamide, 11.66 mg isoniazid-lactose adduct (equivalent to 10 mg isoniazid), 13.33 mg of pyrazinamide-lactose adduct (equivalent to 10 mg pyrazinamide) each dissolved separately in 100 ml of distilled water. From this, one ml of solution was diluted to 10.0 mL with of distilled water to obtain concentration of 10 ppm. All solutionswere scanned in UV-Visible range at 420 and 490 nm (Yates, Jones et al. 2003). Fourier-Transform infrared spectroscopy The Fourier-transform infrared spectroscopy (FTIR) spectra of isoniazid, pyrazinamide, lactose, a isoniazid–lactose physical mixture, pyrazinamide-lactose physical mixture and the isoniazid–lactose adduct, pyrazinamide-lactose were recorded. The spectra were obtained using the diffuse reflectance scan method using KBr on an FT-IR spectrophotometer (IR Affinity 1; Shimadzu, Japan). The scanning range was 400–4000 cm-1. Each sample was scanned 45 times consecutively to obtain FT-IR spectrum. HPLC analysis The HPLC (Gradient) system used for analysis consisted of Agilent Technologies 1200 series equipment, a G1315D quaternary pump, a G1315D diode array detector and a rheodyne injector fitted with a 20  µL loop. Data were recorded and evaluated using the EZChrome Elite software package. Samples were analyzed using LunaC18 column (250 Ãâ€" 4.6 mm i.d. Ãâ€" 5  µm) (Phenomenex) as stationary phase. The mobile phase was water: methanol (95:05, v/v), flow rate of 0.8 mL/min with detection at 266 nm for isoniazid and 269 nm for pyrazinamide. Differential scanning calorimetry Thermal analysis of Isoniazid, pyrazinamide, isoniazid–lactose adduct and pyrazinamide-lactose was performed by differential scanning calorimetry (DSC) using a TA 6000 Mettler toledo thermal analyzer. Individual samples as well as the Maillard adduct (about 2 mg) were weighed in the DSC aluminum pan and were scanned in the temperature range of 25–300 °C. A heating rate of 10 °C/min was used. The thermograms were reviewed for evidence of interaction. Mass Spectrometry The Mass spectrometry was performed using 410 Prostar binary LC with 500 MS with Electro spray Positive ionization and Negative Ionization mode and Mass range is 50-2000 amu. The Isoniazid-lactose, Pyrazinamide-lactose adduct solution dissolved in mobile phase to obtain concentration about 100 µg/mL. In the positive ion mode with electrospray ionization technique, the sample was analyzed. Determination of lactose in pharmaceutical tablet dosage forms The presence of lactose in DOTs tablets was initially examined according to Indian Pharmacopoeia 2007 by taking 5ml saturated solution of tablet powder and then add 5ml 1 M NaOH, Heat and cool at room temperature finally add potassium cupri tatatarate the solution becomes red color shows presence of lactose. Preparation of adduct Sample Prepared in alkaline borate buffer Accurately weighed quantity of Isoniazid 300 mg (equivalent to dose of isoniazid) and 50 mg lactose monohydrate dissolve in alkaline borate buffer pH 9.2 by stirring and ultrasound in 100 ml round bottom flask. In similar way 750 mg pyrazinamide (equivalent to dose of pyrazinamide) was dissolve with 250 mg lactose monohydrate in alkaline borate buffer pH 9.2 in 100 ml round bottom flask. The cleared solutions were refluxed at 600C for 12 hour on water bath. The reaction mixture filtered was diluted with menthol: water (1:1). The adduct was subjected to HPLC analysis (gradient and isocratic run) and Mass spectrometry (LC-MS) analysis. The intensity of brown color was determined was spectrophotometrically after dissolving weighed quantity in distilled water. Docking study The molecular docking tool, GLIDE (Schrodinger Inc., USA) (2006) was used for ligand docking study. The protein preparation was carried out using ‘protein preparation wizard’ in Maestro 9.0. Result UV-Visible spectroscopy The UV-visible absorption spectrum of the isoniazid–lactose adduct and pyrazinamide–lactose adduct had shown an increase in absorption in the visible range as compared with isoniazid and pyrazinamide in distilled water as the solvent. The increased absorption the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier (Shen, Tseng et al. 2007). FT-IR spectroscopy The FT-IR absorption patterns of Isoniazid, Pyrazinamide, lactose, Isoniazid–lactose physical mixture immediately after mixing and pyrazinamide-lactose physical mixture immediately after mixing as well as Isoniazid–lactose adduct, Pyrazinamide-lactose adduct were recorded. The peak at 1678 cm−1 in the IR spectrum of Isoniazid-lactose adduct, 1614 cm−1 Pyrazinamide-lactose adduct can be attributed to the imines formation. The peak of N–H bending is present at 1552 cm−1 and 1583 cm-1 in the IR spectrum of Isonizid and Pyrazinamide and its physical mixture respectively. The peak present in spectrum of Isonizid and Pyrazinamide and its physical mixture are absent in Isoniazid-lactose adduct and Pyrazinamide-lactose adduct both these observations support the formation of adduct. The N–H stretching band of secondary amine appears at 3302 cm−1 and at 3292 cm-1 for Isonizid and Pyrazinamide respectively. The peak for the lactose O–H appears at 3522 cm−1 in the infrared spectra of lactose. The peaks for N–H and O–H stretching appear in the spectrum of the physical mixture, but the peak for N–H disappears in the spectrum of the adduct. This may indicate the reaction of the amine with the red ucing sugar, or it may be due overlapping of N–H stretching peak with that of O–H. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows an interaction between Isoniazid and Pyrazinamide with lactose leading to the formation of a Maillard product (Pavia et al 2009). Differential scanning calorimetry The DSC thermograms show the presence of melting points for isoniazid and pyrazinamide at 171.61ÃŽ ¿C and 189.55 ÃŽ ¿C. The DSC thermogram of lactose shows the peak at 209.83 ÃŽ ¿C. The adduct shows the disappearance of the melting point peak of isoniazid, pyrazinamide, paracetamol and vildagliptine in adduct samples confirms the formation of adduct. Gradient HPLC analysis Initially a gradient run of water and methanol was performed to obtain preliminary information regarding the unknown peaks in maillard reaction products (Shen, Tseng et al. 2007). The mobile phase was optimized to separate the Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was water: methanol (95:05, v/v) with a flow rate 0.8ml/min at ambient temperature. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct elutes at 3.833min and 1.613 min respectively. The control samples for isoniazid and pyrazinamide (without lactose) were also analyzed which proves method selectivity. Isocratic HPLC analysis The optimized isocratic HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak that eluted before Isoniazid and Pyrazinamide elution respectively. Performing analysis under same chromatographic parameters, no another peak was observed in control samples. Mass spectrometry The Isoniazid-lactose and Pyrazinamide-lactose adduct dissolve in mobile phase to obtain drug concentration about 100 µg/ml. In the positive ion mode with electrospray ionization technique, the sample was analyzed. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was protonated molecule ([M+H]+) m/z 463.3 and 448.1 respectively. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct molecular mass was consistent with Isoniazid-lactose adduct and Pyrazinamide-lactose adduct condensation product respectively. The loss of one water molecule from parent leads to maillard-type condensation product. Docking study Isoniazid In docking study, isoniazid shows binding with ARG-38 amino acid in the selected structure of protein (PDB code: 3I6N) and isoniazid-lactose adduct shows binding with ASN-72, SER-69, SER-173, ALA-134 and PRO-132 amino acid in the selected structure of protein (PDB code: 3I6N) as shown in Table No. 1.1. Pyrazinamide Pyrazinamide shows binding with ALA-131 amino acid in the selected structure of protein (PDB code: 3PL1) and pyrazinamide-lactose adduct shows binding with ASP-133 and LEU-131 amino acid in the selected structure of protein (PDB code: 3PL1). Discussion On the above observation difficulties in the formulating a new pharmaceutical dosage form have often experienced because of the interaction between the lactose and active ingredients itself i.e. isoniazid and pyrazinamide. Although the nature and intensity of this interaction may alter the stability, dissolution rate and consequently absorption of the drug and also affect the pharmacological effect. it indicates that such interactions involving in the formation of the complexes and it studied by different analytical techniques. The UV results shows increased absorption in the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier in Shen, Tseng et al. 2007. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows peak of C=N it shows that formation of a Maillard product. HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak of impurity or maillard reaction product that eluted before Isoniazid and Pyrazinamide elution respectively. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct and it has same molecular weight related to maillard-type condensation product. In the docking study of isoniazid adduct and pyrazinamide adduct shows more binding than isoniazid and pyrazinamide but this is pseudo results because this binding present at hydroxyl group and hydroxyl group are responsible for the increase excretion of the isoniazid and pyrazinamide and it may be reduces the therapeutic effect of isoniazid and pyrazinamide. In spite of that analytical study confirm the occurrence of maillard reaction product in lactose containing solid dosage forms of amino functional group containing drugs but lactose is still preferred as excipient in the isoniazid and pyrazinamide containing anti-tubercular formulation i.e. DOT’s. Conclusion The present study reports that antitubercular drugs i.e. isoniazid and pyrazinamide undergoes maillard reaction and that confirmed by UV, FT-IR, HPLC and MS. The docking study of isoniazid adduct and pyrazinamide adduct more binding than isoniazid and pyrazinamide but it is pseudo results pharmacologically the excretion of isoniazid and pyrazinamide increase and it ultimately reduces the therapeutic activity. A drugs- excipient interaction study can be actively used to the advantage of the formulator to increase the bioavailability of the drug. By compiling the data the use of lactose in the formulation of isoniazid and pyrazinamide, secondary amines needs to reconsideration. References: Chadha, R. and S. Bhandari (2014). Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques. Journal of pharmaceutical and biomedical analysis87: 82-97. Crowley, P. J. (1999). Excipients as stabilizers. 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Mode of Binding of the Tuberculosis Prodrug Isoniazid to Heme Peroxidases BINDING STUDIES AND CRYSTAL STRUCTURE OF BOVINE LACTOPEROXIDASE WITH ISONIAZID AT 2.7 Ã… RESOLUTION.Journal of biological chemistry, 285(2): 1569-1576. Shen, S.-C., et al. (2007). An analysis of Maillard reaction products in ethanolic glucose–glycine solution. Food chemistry102(1): 281-287. Wirth, D. D., et al. (1998). Maillard reaction of lactose and fluoxetine hydrochloride, a secondary amine. Journal of pharmaceutical sciences87(1): 31-39. Yates, E. A., et al. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. Journal of Materials Chemistry13(9): 2061-2063.